Synthesis and assessment of a maleimide functionalized BF2 azadipyrromethene near-infrared fluorochrome.
نویسندگان
چکیده
The first water soluble maleimide bearing NIR BF2-azadipyrromethene (NIR-AZA) fluorochrome has been synthesised which is capable of rapid thiol conjugations in water with peptides such as glutathione, the cell penetrating peptide (CPP) C(β-A)SKKKKTKV-NH2 and a thiol substituted cRGD. NIR fluorescence imaging showed rapid cellular delivery of the CPP conjugate and effective in vivo tumour localization for the cRGD conjugate.
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عنوان ژورنال:
- Chemical communications
دوره 51 93 شماره
صفحات -
تاریخ انتشار 2015